PRODUCTS
ZytoLight ® SPEC MEF2D/BCL9 TriCheckTM Probe
The ZytoLight SPEC MEF2D/BCL9 TriCheckTM Probe is designed to detect inversions involving the chromosomal region 1q21.2 harboring the BCL9 gene and the chromosomal region 1q22 harboring the MEF2D gene. Rearrangements of the myocyte enhancer factor 2D (MEF2D) have been frequently found in acute lymphoblastic leukemia (ALL).
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2277-50 |
|
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
is designed to detect inversions involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene and the chromosomal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.
ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.
