PRODUCTS
ZytoLight ® SPEC FOXO1/PAX3 TriCheckTM Probe
The ZytoLight ® SPEC FOXO1/PAX3 TriCheckTM Probe is designed to detect translocations involving the FOXO1 (a.k.a. FKHR) gene and the PAX3 gene.
Alveolar rhabdomyosarcoma (ARMS) is characterized by two tumor-specific translocations:
- t(2;13)(q36;q14.1) involving FOXO1 and PAX3
- t(1;13)(p36.1;q14.1) involving FOXO1 and PAX7
PAX7-FOXO1 is less common but is associated with a better prognosis than PAX3-FOXO1 fusion. The translocations and their fusion genes represent highly specific genetic markers useful in the diagnosis and prognosis of ARMS.
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2185-50 |
|
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
