PRODUCTS
ZytoLight ® SPEC D13S319/13q34 Dual Color Probe
The ZytoLight SPEC D13S319/13q34 Dual Color Probe is designed for the detection of deletions on the long arm of chromosome 13. Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the Western population. The most frequent aberration in CLL is the deletion of 13q14.2 which involves the D13S319 locus and which is associated with a favorable prognosis if occurring as the sole genetic aberration.
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2280-50 |
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
is designed to detect inversions involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene and the chromosomal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.
ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.
