PRODUCTS
ZytoLight ® SPEC FGFR3/IGH Dual Color Dual Fusion Probe
The ZytoLight SPEC FGFR3/IGH Dual Color Dual Fusion Probe is designed to detect the translocation t(4;14)(16.3;q32.3) affecting the FGFR3 (fibroblast growth factor receptor 3, a.k.a. JTK4) gene in the chromosomal region 4p16.3 and IGH (immunoglobulin heavy chain locus, a.k.a. IGH@) locus in 14q32.33. FGFR3/IGH translocations are observed in approximately 15-20% of patients with multiple myeloma (MM).
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2282-50 |
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
is designed to detect inversions involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene and the chromosomal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.
ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.
