ZytoLight ® SPEC MAF/IGH Dual Color Dual Fusion Probe

The ZytoLight SPEC MAF/IGH Dual Color Dual Fusion Probe is designed to detect the translocations affecting the MAF gene in the chromosomal region 16q23.2 and the IGH locus in 14q32.33. The translocation t(14;16)(q32.3;q23) is frequently found in multiple myeloma (MM).

Five recurrent primary translocations involving the immunoglobulin heavy chain (IGH) locus have been identified; they include t(11;14)(q13.3;q32.3), t(6;14)(p21.1;q32.3), t(4;14)(p16.3;q32.3), t(14;16)(q32.3;q23), and t(14;20)(q32.3;q12), which involve the genes CCND1, CCND3, FGFR3 and NSD2, MAF, and MAFB, respectively. All of these translocations lead to the dysregulation and overexpression of the target genes as a consequence of their juxtaposition to regulatory sequences of the IGH locus.


Probe Maps

 

Ordering Information

Prod. No.:Tests¹ (Volume):Intended Use²:
Z-2270-50
5 (50 µl)
CE IVD
 

Download Information

 
 
 

1 Using 10 μl probe solution per test.
2 CE IVD only available in certain countries. All other countries research use only!
Please contact your local dealer for more information.

 
ISO 9001
ISO 13485
AEO
ZytoVision GmbH

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