PRODUCTS
ZytoLight ® SPEC 11q gain/loss Triple Color Probe
The ZytoLight SPEC 11q gain/loss Triple Color Probe is designed to detect 11q alterations. A subset of lymphomas with gene expression and pathological characteristics of Burkitt lymphomas (BL) but absence of MYC translocation has been recently described which carries 11q proximal gains and telomeric losses.
The current WHO classification introduced this new provisional entity as Burkitt-like lymphoma with 11q aberration. The minimal region of gain (MGR) and loss (MLR) was defined at 11q23.3 and at 11q24.1-q25, respectively.
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2216-50 |
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
is designed to detect inversions involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene and the chromosomal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.
ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.
