PRODUCTS
ZytoLight ® SPEC MAFB/IGH Dual Color Dual Fusion Probe
The ZytoLight ® SPEC MAFB/IGH Dual Color Dual Fusion Probe is designed to detect the translocations affecting the MAFB gene in the chromosomal region 20q12 and the IGH locus in 14q32.33. The translocation t(14;20)(q32.3;q12) is frequently found in multiple myeloma (MM).
Five recurrent primary translocations involving the immunoglobulin heavy chain (IGH) locus have been identified; they include t(11;14)(q13.3;q32.3), t(6;14)(p21.1;q32.3), t(4;14)(p16.3;q32.3), t(14;16)(q32.3;q23), and t(14;20)(q32.3;q12), which involve the genes CCND1, CCND3, FGFR3 and NSD2, MAF, and MAFB, respectively. All of these translocations lead to the dysregulation and overexpression of the target genes as a consequence of their juxtaposition to regulatory sequences of the IGH locus.
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2271-50 |
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
