PRODUCTS
ZytoLight ® SPEC PTPRT/20q11 Dual Color Probe
The ZytoLight SPEC PTPRT/20q11 Dual Color Probeis designed to detect deletions of the long arm of chromosome 20. 20q deletions can occur in various myeloid disorders, e.g., myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPNs).
The minimal common deleted region (CDR) was defined to be flanked by the genes PTPRT (20q12) and EYA2 (20q13.12).
Probe Maps
Ordering Information
| Prod. No.: | Tests¹ (Volume): | Intended Use²: | ||
|---|---|---|---|---|
| Z-2213-50 |
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Download Information
| 1 | Using 10 μl probe solution per test. |
| 2 | CE IVD only available in certain countries. All other countries research use only! Please contact your local dealer for more information. |
is designed to detect inversions involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene and the chromosomal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.
ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.
