FlexISH ® ALK/ROS1 DistinguISHTM Probe
The FlexISH ® ALK/ROS1 DistinguISHTM Probe is designed to detect rearrangements involving the ALK (anaplastic lymphoma receptor tyrosine kinase) and ROS1 (c-ros oncogene 1) gene, respectively. Using this probe, it is possible to simultaneously detect ALK and ROS1 rearrangements and, additionally, to discriminate between possible aberrations affecting these chromosomal regions.
Both, the ALK as well as the ROS1 gene, encode for transmembrane receptor tyrosine kinases. Rearrangements affecting the ALK or the ROS1 gene locus are frequently found in non-small cell lung cancer (NSCLC). ALK and ROS1 positive NSCLC patients benefit from a tyrosine kinase targeted therapy, like, e.g., crizotinib.
|Prod. No.:||Tests¹ (Volume):||Intended Use²:|
|1||Using 10 μl probe solution per test.|
|2||CE IVD only available in certain countries. All other countries research use only!
Please contact your local dealer for more information.